Research Paper no.27

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Antimicrobial and Antibiofilm Activities of Weissella cibaria Against Pathogens of Upper Respiratory Tract Infections

Source : Microorganisms 2021;9(6):1181 / SCI / in vitro
Authors : Ji-Eun Yeu, Hyeon Gyu Lee, Geun-Yeong Park, Jisun Lee and Mi-Sun Kang


The antimicrobial activities of W. cibaria were compared with those of other oral probiotics using a competitive inhibition assay and the determination of the minimum inhibitory concentrations (MICs). In addition, a time-kill assay, spectrophotometry, and confocal laser scanning microscopy were used to confirm the antimicrobial and antibiofilm abilities of W. cibariaCMU (oraCMU) and CMS1 (oraCMS1). Both live cells and cell-free supernatants of all tested probiotics, except Streptococcus salivarius, showed excellent antimicrobial activities. All target pathogens were killed within 4 to 24 h at twice the MIC of oraCMU and oraCMS1, which showed the highest antimicrobial activities against M. catarrhalis. The antimicrobial substances that affected different target pathogens were different. Both oraCMU and oraCMS1 showed excellent abilities to inhibitbiofilm formation and remove preformed biofilms.

Our results suggest that the W. cibaria probiotics offer new possibilities for the prevention and treatment of bacterial URTIs.

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