FOR ORAL HEALTH & TECHNOLOGY
[Adhesive Properties]
According to the results of the clinical trial, which compared probiotics’ adhesive properties, active oraCMU® was still
observed on the surface of oral cavity of 84% of participants, who stopped taking oraCMU® 4 weeks ago.
[Suppression of Bad-Smelling Compounds]
oraCMU® was proved to be the most effective in suppressing VSC and bad breath compared With 4 other probiotic strains.
[Coaggregation with Bacteria Which Cause Oral Diseases]
A comparative study of coaggregation of probiotics with bacteria, which cause oral diseases, found that oraCMU® more
effectively disrupts bacterial activities leading to halitosis and periodontitis and prevents oral diseases than all other
probiotic strains concerned.
[Antibacterial Activities against Bacteria That Cause Halitosis or Periodontitis]
A comparative study of antibacterial activities of probiotics found that oraCMU® is more effective to inhibit growth in
bacteria which cause halitosis and periodontitis than all other probiotic strains concerned.
oraCMU® (Weissella cibaria CMU) and oraCMS1® (Weissella cibaria CMS1) are our patented probiotics. Both probiotic strains that promote oral health were isolated from the saliva of 460 kids, who had healthy mouth.
[Low Caries Risk]
A comparative study of PAV of probiotic strains in carbohydrates found that oraCMU® is the least likely to influence the development of dental caries.
[Significant Reduction in Plaque]
The clinical trial to investigate the efficacy of probiotic strains in preventing dental caries discovered that oraCMU® has greater inhibitory effects on plaque formation than probiotic strains provided by other companies.
[Inhibition of Plaque Formation by S. Mutans]
A comparative study of probiotic strains’ inhibitory effects on plaque formation by bacteria(S. mutans) that cause dental caries discovered that oraCMU® inhibits plaque formation most efficiently.
A Combination of Mechanisms of Action
1. Coaggregation of the probiotics
Coaggregation of the probiotics with pathogenic bacteria enables the probiotics to block the adherence of pathogenic bacteria to epithelial cells and teeht and contribute to the elimination of pathogenic bacteria.
2. Suppression of biofilm generation
Bacteria that cause dental caries metabolize produce sticky substances, which contribute to plaque formation. Inhibit such bacterial activities in the oral cavity, thereby blocking biofilm (tartar or dental plaque) formation.
3. Secretion of 4 antimicrobial substances
Secretes antimicrobial substances such as organic acids, hydrogen peroxide, fatty acids, and bacteriocin outsice of cells, thereby inhibiting the growth of bacteria which cause halitosis and periodontitis.
4. Competition with pathogens for binding sites on epithelial cells
Block th adherence of pathogens, which cause halitosis or periodontitis, to epithelial cells, thereby preventing various orla diseases.
5. IInhibition of enzyme activity and gene expression related to VSC production
Inhibit mgl gene expression in P.gingivalis, the bacteria which produce VSC, the main cause of bad breah.
The probiotics also inhibigt and block METase activities.
6. The inhibition of formation of substances that promote cellular inflammation
Inhibit the production of substances (NO, IL-1B, and IL-6, all of which promote inflammation) induced by general probiotics for oral health.
Our patented probiotics. Offer a fundamental solution to various oral health problems. Help to restore the balance of your oral microbiome.
