Pioneered by Dr. Jong-Suk Oh

A Revolution in Oral Health through Probiotic Research

Dr. Jong-Suk Oh's journey in probiotic research for oral health began at the UCLA School of Dentistry. Frustrated with his own persistent oral health issues despite diligent care, Dr. Oh knew that conventional oral hygiene methods—such as toothbrushes, floss, and mouthwash—simply weren't enough to address the root of the problem. This led him to explore innovative alternatives.

As Dr. Oh delved into the world of microbiome studies, he uncovered both the underlying causes of these issues and potential solutions. His breakthrough realization was that probiotics held the key to revolutionizing oral health management.

Our research institute traces its roots back to 1997, when Dr. Oh first investigated the potential of probiotics for oral health at Chonnam National University's Medical School in South Korea. Under his leadership, the research team recognized the promising potential of probiotics as a next-generation solution for oral care. They worked tirelessly to isolate specific probiotic strains with beneficial properties for preventing and managing oral diseases.

By identifying and naming these unique strains, the team unlocked their transformative potential, paving the way for a new era in oral health management. Today, we continue to build upon Dr. Oh's pioneering work, committed to advancing the science and practice of oral care through the power of probiotics.

OraTicx! Leader of the oral microbiome

Based on Continuous Research


OraTicx Labs

R&D company with an in-house research lab specialized in oral health

Research Area

Probiotics for Holistic Oral Health


No. Citation References Research Level Title Date
33 SCIE Front. Microbiol. 2023; 14:1108762. / SCIE / Clinical Clinical trial Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial 2023.01
32 KCI Korean J Oral Anatomy. 2022; 43(1):75-85. in vitro Heat-inactivated Weissella cibaria CMU downregulates the mRNA expression of proinflammatory cytokines and matrix metalloproteinases in Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts 2022.12
31 SCIE Medicina 2022;58:1310 Pre-clinical trial Therapeutic efficacy of Weissella cibaria CMU and CMS1 on allergic inflammation exacerbated by diesel exhaust particulate matter in a murine asthma model 2022.09.
30 SCIE Probiotics Antimicrob Proteins 2022;14(4):760-766 in vitro In vitro inactivation of respiratory viruses and rotavirus by the oral probiotic strain Weissella cibaria CMS1 2022.05.
29 SCIE Toxicological Research 2022;38:293-310 in vitro Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity 2022.01.
28 SCIE Microorganisms 2021;9(12):2482 in vitro In vitro evaluation of the effect of oral probiotic Weissella cibaria on the formation of multi-species oral biofilms on dental implant surfaces 2021.12.
27 SCIE Microorganisms 2021;9(6):1181 in vitro Antimicrobial and antibiofilm activities of Weissella cibaria against pathogens of upper respiratory tract infections 2021.05.
26 SCIE Int J Environ Res Public Health 2021;18(9):4674 Clinical trial A randomized, double-blind, placebo-controlled trial to assess the acidogenic potential of dental biofilms through a tablet containing Weissella cibaria CMU 2021.04.
25 SCIE Int J Environ Res Public Health 2021;18(3):1143 Clinical trial Effects of oral probiotics on subjective halitosis, oral health, and psychosocial health of college students: a randomized, double-blind, placebo-controlled study 2021.01.
24 KCI J Korean Acad Oral Health 2020;44(4):246-252 Clinical trial Inhibitory effect of the probiotic bacteria, Weissella cibaria CMU on halitosis: a randomized placebo-controlled study 2020.12.
23 KCI J Korean Soc Dent Hyg 2020;20(5):753-762 Clinical trial Effect of probiotics intake on oral environment changes of the elderly in long-term care facilities 2020.09.

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No. Citation References Research Level Title Date
22 SCIE Mol Med Rep 2020;22(5):4143-4150 in vitro Weissella cibaria CMU exerts an anti-inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans-induced NF-κB activation in macrophages 2020.09.
21 SCIE BMC Oral Health 2020;20:243 Clinical trial Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomized, double-blind, placebo-controlled trial. 2020.09.
20 SCIE J Med Food 2020;23(6):649-657 Clinical trial Reduction of halitosis by a tablet containing Weissella cibaria CMU: A randomized, double-blind, placebo-controlled study 2020.06.
19 SCIE J Periodontol 2020;91(10):1237-1374 Pre-clinical trial Effect of W. cibaria on the reduction of periodontal tissue destruction in mice 2020.02.
18 KCI Int J Oral Biol 2019;44(4):152-159 in vitro Weissella cibaria CMU suppresses mgl gene expression and enzyme activity associated with bad breath 2019.12.
17 SCIE J Vet Dent 2019;36(2):135-142 Pre-clinical trial Effects of Weissella cibaria CMU on halitosis and calculus, plaque, and gingivitis indices in Beagles 2019.09.
16 SCIE Int J Mol Sci 2019;20(11):2693 in vitro Safety evaluation of oral care probiotics Weissella cibaria CMU and CMS1 by phenotypic and genotypic analysis 2019.05.
15 KCI Int J Oral Biol 2018;43(4):193-200 in vitro Effect of natural extracts on oral care probiotics Weissella cibaria CMU and periodontal pathogens 2018.12.
14 SCOPUS Indian J Public Health 2018;9(9):1163 Clinical trial Clinical studies on the dental caries prevention effects of the ability of Weissella cibaria CMU to adhere to the oral cavity 2018.10.
13 - J. Milk Sci Biotechnol 2018;36(3):171-177 in vitro Enhancement of viability of Weissella cibaria CMU by low-temperature encapsulation 2018.09.
12 SCIE Molecules 2018;23(8):1984 in vitro Characterization of antibacterial cell-free supernatant from oral care probiotic Weissella cibaria CMU 2018.08.
No. Citation References Research Level Title Date
11 KCI Korean J Vet Res 2018;58(2):87-94 Pre-clinical trial Oral malodor-reducing effects by oral feeding of Weissella cibaria CMU in Beagle dogs 2018.05.
10 SCIE Genome Announc 2017;5(40):e01103-17 in vitro Complete genome sequences of Weissella cibaria strains CMU, CMS1,CMS2, and CMS3 isolated from infant saliva in South Korea 2017.10.
9 SCIE Molecules 2016;21(12):1752 in vitro Comparative study on the characteristics of Weissella cibaria CMU and probiotic strains for oral care 2016.12.
8 KCI Chonnam Med J 2012;48(3):159-163 in vitro Comparison of temperature and additives affecting the stability of the probiotic Weissella cibaria 2012.12.
7 KCI J Bacterol Virol 2011;41(1):17-26 in vitro Effect of Weissella cibaria on Fusobacterium nucleatum-induced interleukin-6 and interleukin-8 production in KB cells 2011.03.
6 KCI J Bacterol Virol 2009;39(4):1-11 in vitro Quantitative analysis of Weissella cibaria against periodontopathic bacteria by real-time PCR 2009.12.
5 SCIE FEMS Microbiol Lett 2009;292(1):33-41 in vitro Molecular characterization and expression analysis of the glucansucrase DSRWC from Weissella cibaria synthesizing a α(1→6)glucan 2009.01.
4 SCIE Caries Res 2006;40(5):418-425 in vitro Clinical trial Effect of Weissella cibaria isolates on the formation of Streptococcus mutans biofilm 2006.08.
3 SCIE J Clin Periodontol 2006;33(3):226-232 in vitro Clinical trial Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds 2006.02.
2 KCI J Bacterol Virol 2006;36(3):151-157 in vitro Adhesion of Weissella cibaria to the epithelial cells and factors affecting its adhesion 2006.09.
1 SCIE FEMS Microbiol Lett 2005;253(2):323-329 in vitro Coaggregation ability of Weissella cibaria isolates with Fusobacterium nucleatum and their adhesiveness to epithelial cells 2005.10.