Research Paper no.36
Effect of the probiotic Weissella cibaria CMS1 on the immune response and the oral microbiome: a randomized, double-blind, placebo-controlled, parallel study
Source: Food Funct., 2024, Advance Article
Authors: Min Ju Park, Soo-yeon Park, Kyeong Jin Kin, Bumjo Oh, and Ji Yeon Kim
Published: April 2, 2024
The oral cavity connects to the external environment and plays a key role in both our respiratory and digestive systems. It hosts a complex community of microbes that are crucial for our overall health and immune defense. Recently, there's been growing interest in using probiotics to prevent and treat diseases. This study investigated the effects of consuming Weissella cibaria CMS1 (W. cibaria CMS1), a type of probiotic, on the oral microbiome and immune function in healthy people over a 12-week clinical trial. The trial was randomized, double-blind, and placebo-controlled, involving 90 healthy participants.
The results showed that consuming W. cibaria CMS1 led to a significant increase in salivary immunoglobulin A, an important immune marker (p = 0.046), and a decrease in tumor necrosis factor-alpha (TNF-α), a marker of inflammation (p = 0.008). The analysis also found changes in the diversity and composition of the oral microbes. Specifically, there was an increase in Firmicutes and Actinobacteria, and a decrease in Bacteroidetes and Fusobacteria. Notable increases were seen in various beneficial bacterial strains such as Lactobacillales, Bacilli, Streptococcaceae, and Streptococcus after 12 weeks of consuming the probiotic. Furthermore, certain types of Fusobacterium were linked to TNF-α levels. These results highlight the positive impacts of W. cibaria CMS1 on oral health and immune function.
To delve deeper into the findings of this research paper, we invite you to explore the comprehensive results by visiting the following link: https://doi.org/10.1039/D4FO00195H.
This link will take you directly to the publication, where you can access the full text and gain a deeper understanding of the study's outcomes. Happy reading!
Fig.3
Changes in salivary IgA for 12 weeks with the moderator variable “PSQI” and a split point of 2.5. Weissella cibaria CMS1 is more effective than placebo for participants in the red leaves, and the reverse is valid for green leaves. Violin plots comparing the distribution of the placebo (gray) and W. cibaria CMS1 (green) groups. The interquartile range and median are shown by the vertical bar and black dash, respectively, and the mean is shown by the red dot. P values were assessed using a linear mixed-effects model adjusted with alcohol amount at the baseline. PSQI, Pittsburgh sleep quality index; Ig, immunoglobulin.
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